Vice President, Global Medical Lead - MASH at Madrigal Pharmaceuticals in Conshohocken, PA

Job description

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Global Medical Lead, MASH serves as the single point of accountability for Madrigal’s integrated global medical strategy and plan across the MASH portfolio. Partnering closely with Medical Affairs leaders, this individual brings together diverse expertise to align priorities and investments, and drives coordinated execution across evidence generation, scientific engagement, diagnostics, lifecycle planning, and external partnerships, with execution led by the relevant specialist functions. Through collaboration with key cross-functional stakeholders, medical perspectives are incorporated early into enterprise decisions and translated into aligned business and development strategies. Leading a team of Medical Directors supporting MASH, the Global Medical Lead fosters a high-performing leadership team that drives scientific excellence, navigates tradeoffs, and delivers the integrated MASH strategy to maximize patient impact and portfolio value. Key Responsibilities 1. Integrated MASH Medical Strategy & Portfolio Leadership Own the integrated global MASH medical plan and strategy across resmetirom and future MASH assets, ensuring it is scientifically rigorous, strategically aligned, and operationally deliverable across all priority markets, functions, and stages of the product lifecycle. Partner closely with Medical Affairs leaders to align priorities across evidence, stakeholder engagement, lifecycle planning, and intended outcomes, ensuring all Medical functions work from one coordinated corporate asset plan. Translate the MASH medical strategy into clear, actionable medical objectives with measurable outcomes and priorities that guide functional strategies and execution across the organization. Incorporate perspectives from a wide variety of markets to ensure the strategy continually reflects differences in healthcare systems, patient populations, clinical practice, access environments, and treatment pathways while frequently adjusting priorities and investments in response to changing evidence, stakeholder needs, market dynamics, and portfolio opportunities. Own medical prioritization and tradeoff decisions across the MASH portfolio, balancing investment, resources, and organizational focus across competing opportunities to maximize impact. Champion AI-enabled and innovative approaches that improve the speed, quality, and effectiveness of strategic planning and execution across the MASH portfolio. 2. Integrated Evidence, Engagement, and Communication Priorities Own the integrated evidence strategy for the MASH portfolio, leading the development and prioritization of asset-level evidence priorities and areas of interest (AOIs) and aligning scientific questions, unmet needs, evidence gaps, and stakeholder needs to focus investment on the highest-value opportunities. Partner with leaders for evidence generation and other re