Senior Scientist I, Cancer Immunology at Revolution Medicines in Redwood City, CA

Job description

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide. Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients. The Opportunity: As a key player in our Cancer Immunology team, you will use your immuno-oncology expertise to help advance Revolution Medicines’ assets in preclinical and clinical development. Responsibilities: Design, develop, validate and execute in vitro, in vivo, and ex vivo studies to address key translational questions and support immuno-oncology biomarker plans. Identify, evaluate and implement emerging technologies to enhance translational biomarker discovery and mechanistic understanding. Drive reverse translation efforts by formulating and testing hypotheses derived from clinical finding as appropriate to inform clinical development plans. Stay abreast of advances in tumor immunology and immunotherapy, identifying novel combination strategies and contributing to preclinical evaluation. Analyze, interpret, and communicate complex data effectively across internal cross-functional teams and at external scientific meetings. Represent Revolution Medicines at scientific conferences and other external engagements. Required Skills, Experience and Education: D. in immunology, cancer biology, or a related discipline, with deep expertise in tumor immunology, immuno-oncology biomarkers, and/or immunotherapy. Proven track record of research excellence, evidenced by high-impact publications. Expertise in in vivo model design to evaluate the efficacy and mechanisms of action of therapeutic agents and enable biomarker discovery, both internally and via contract research organizations. Strong technical expertise in immunology techniques including multi-parameter flow cytometric analyses, primary human cellular/tissue-based functional assays, cell biology and molecular biology to guide/inform mechanism of action and biomarker discovery. Strong problem-solving skills and ability to independently oversee scientific projects, rigorously analyze and interpret scientific data while maintaining attention to detail. Excellent written and verbal communication skills. Thrives in a fast-paced, collaborative, interdisciplinary team setting. 4+ years of relevant biotech or pharmaceutical industry experience in oncology drug discovery and development. Preferred Skills: Hands-on experience with humanized mouse models is desirable. Familiarity with multiomics analyses and integrating computational insights into experimental designs. #LI-SB1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an