Senior Scientist, CMC Analytical Development at Cytokinetics in San Francisco, CA

Job description

Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction. We welcome exceptional individuals to join us in our mission to develop potential medicines to improve the health span of people with cardiovascular diseases of impaired muscle function. We are seeking a highly skilled and motivated Analytical Chemist with expertise in analytical development and laboratory studies. The ideal candidate is an experienced analytical professional with proven track records in laboratory studies, Analytical Development, Quality Control, and technical support to Drug Substance and Drug Product manufacturing processes. This position offers an exciting opportunity to contribute to the development of novel therapeutics, support the launch of a new commercial product, and to work in a dynamic and collaborative cross functional team environment. Job purpose We are seeking a highly motivated and hands-on Senior Scientist, Analytical Development, to support in-house analytical development activities across Cytokinetics' small molecule pipeline. This laboratory-based role will be responsible for designing and executing analytical studies to support drug substance and drug product development from early-stage research through clinical development. The successful candidate will apply scientific expertise in chromatographic, spectroscopic, and physicochemical characterization techniques to solve technical challenges, generate high-quality data, and support critical development decisions. Working closely with Process Chemistry, Pharmaceutical Development, DMPK, Manufacturing, and Quality functions, this individual will contribute to analytical method development, product characterization, investigation activities, and continuous improvement initiatives in a collaborative team environment. Responsibilities Design, execute, and document analytical studies supporting drug substance and drug product development. Develop, optimize, qualify, and troubleshoot analytical methods used for release, stability, characterization, and process support testing. Perform hands-on laboratory testing using chromatographic, spectroscopic, and physicochemical analytical techniques. Characterize drug substances, intermediates, degradation products, excipients, and drug products to support development programs. Generate, analyze, interpret, and present scientific data to support development decisions and project milestones. Collaborate with Process Chemistry, Formulation Development, DMPK, Pharmacology, and Manufacturing teams to address analytical and technical challenges. Support analytical investigations associated with atypical results, laboratory events, and method performance issues. Maintain laboratory instruments and equipment, including calibration, qualification, troubleshooting, and routine maintenance activities. Prepare and review analytical protocols, study reports, technical summaries, and laboratory documentation. Support analytical method transfers, validation activities, specification development, and stability studies as needed. Contribute to laboratory operational excellence through process improvements, scientific innovation, and knowledge sharing. Ensure laboratory activities are conducted in accordance with applicable procedures, quality standards, and regulatory expectations. Strive for a collaborative, innovative, and results-oriented analytical development culture. undefined Qualifications BS/MS in Analytical Chemistry, Chemistry, Pharmaceutical Sciences, or a related discipline; PhD preferred but not required. 5+ years of pharmaceutical industry experience in analytical development, quality control, or related analytical laboratory environments. Strong hands-on experience with analytical characterization of small molecule drug substances