Senior Principal Scientist, Medicinal Chemistry at Schrödinger in Tokyo

Job description

We’re looking to hire a Senior Principal Scientist of Medicinal Chemistry to join us in our mission to discover and develop drugs that improve human health through the use of breakthrough computational methods. Our drug discovery and pre-clinical development team includes a cross-functional group of scientists and drug developers with experience working on all common target classes and therapeutic areas. We’re supported by more than 100 software developers and engineers, as well as a large-scale computational infrastructure to apply our proprietary physics-based drug design and optimization platform. Several programs we have worked on have achieved development candidates, including progression to clinical development and FDA approval. View our entire pipeline of wholly-owned programs and collaborations here. Who will love this job: A passionate scientist with a robust background in structure-based drug design A team player skilled at working in a dynamic, multidisciplinary environment An excellent communicator and presenter A dedicated collaborator who enjoys working with geographically distributed teams What you’ll do: Lead drug discovery programs in effective collaboration with global cross-functional teams, accounting for differences in time zone and work culture Execute medicinal chemistry strategies to deliver high-quality development candidates Collaborate effectively with computational chemists and modelers on the application of Schrödinger’s computational platform for rapid advancement of drug discovery programs Drive continuous improvement and implementation of new strategies for our Therapeutics Group’s experimental hit-finding capabilities Provide strategic and technical expertise to the Medicinal Chemistry team and the broader Therapeutics Group What you should have: PhD in synthetic organic or medicinal chemistry, or a related field At least ten years of drug discovery experience in a pharmaceutical and/or biotech setting Demonstrated track record in medicinal chemistry, as evidenced by successful advancement of drug discovery projects to clinical candidate nomination Excellent understanding of biology, pharmacology, drug metabolism and pharmacokinetics Demonstrated experience and expertise with modern experimental hit-finding techniques Extensive experience working with external chemistry teams at CROs Business-level proficiency in English and Japanese Hands-on experience advancing peptide modality programs is a plus Pay and Perks: Schrödinger understands that it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, bonus plan, and benefits, which includes mutual-aid retirement plans, over three weeks of paid vacation time, numerous company holidays, a parental leave program, and healthcare through our partnership with the Japanese Health Insurance Association, and professional development opportunities including trainings and continuous education support. Why Schrödinger: You will join a global scientific organization developing and applying advanced computational technologies to improve human health and quality of life. This role offers the opportunity to work with leading life-science organizations in Japan, contribute to important scientific challenges, collaborate with international experts, and shape the adoption of next-generation computational methods in drug discovery. 募集ポジション：Senior Principal Scientist, Medicinal Chemistry 勤務地：日本・東京 Schrödingerでは、革新的な計算科学的手法を活用し、人々の健康向上に貢献する医薬品の創出・開発を目指して、メディシナルケミストリー分野の Senior Principal Scientist をを募集しています。 当社の創薬・前臨床開発チームは、主要な標的クラスおよび幅広い治療領域での経験を持つ、多様な専門分野の研究者と医薬品開発の専門家で構成されています。100名以上のソフトウェア開発者・エンジニアと大規模な計算インフラ支援のもと、物理学に基づく当社独自の分子設計・最適化プラットフォームを創薬に活用しています。当社が携わった複数のプログラムから開発化合物が創出されており、臨床開発への移行や米国食品医薬品局（FDA）の承認に至った実績もあります。当社が単独で権利を保有するプログラムおよび共同研究プログラムを含むパイプラインの全体像は、 こちら をご覧ください。 このような方に最適なポジションです 構造に基づく創薬・分子設計に関する確かな専門知識と経験を持ち、研究に情熱を注げる方 変化の早い、多様な専門分野が交わる環境で、チームの一員として力を発揮できる方 優れたコミュニケーション能力とプレゼンテーション能力のお持ちの方 地域をまたいで活動するチーム