Senior Director, Medical Capabilities at Arrowhead Pharmaceuticals in Pasadena, CA

  • Company: Arrowhead Pharmaceuticals
  • Location: Pasadena, California, United States
  • Salary: $280K – $300K
  • Job type: full time
  • Workplace: onsite
  • Posted: 2026-10-21

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Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position Let's do something amazing together! We are seeking a Senior Director, Medical Capabilities, to lead the team responsible for scientific medical resources, Medical Information, and medical review across Arrowhead's commercialized and pipeline portfolio, primarily focused on the cardiometabolic therapeutic area. This leader will set priorities, build reliable processes, and develop colleagues while remaining a hands-on contributor to high-priority deliverables. The role ensures that Medical Affairs materials and responses are accurate, balanced, current, useful to their intended audiences, and delivered on time. The Senior Director partners with Medical Affairs colleagues including Field Medical, Medical Strategy, Evidence Generation and Dissemination, Clinical Development, Regulatory, Safety, Legal, and Commercial, as appropriate, and reports to the Group Vice President of Medical Affairs. This role is based in Pasadena with an expectation to be in office 5 days a week. Responsibilities Capability and Team Leadership Lead, coach, and develop a team spanning medical resources, Medical Information, and medical review with global purview; define roles, standards, capacity, and development plans. Own an integrated, prioritized workplan with clear owners, due dates, review milestones, and weekly status reporting; identify risks early and resolve or escalate barriers. Develop and maintain scalable processes, training, quality checks, and systems for intake, authoring, review, and retirement of content. Balance strategic direction with personal execution: directly create, critically edit, review, and deliver priority work when scientific complexity, timing, or capacity requires it. Medical Resources and Scientific Content Lead the development and lifecycle management of cardiometabolic disease state and product resources, slide decks, field tools, FAQs, training materials, and congress resources for internal and external scientific exchange. Translate clinical, real-world, and published evidence into clear, accurate, appropriately referenced scientific narratives; tailor content to approved audience and use. Partner with Medical Affairs colleagues including Medical Strategy, Field Medical, Evidence Generation and Dissemination, and other scientific colleagues to identify content gaps, prioritize updates, and roll out resources with practical training and version

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