Senior Director, Clinical Practice Liaison Team- East Region at Madrigal Pharmaceuticals in Philadelphia, PA

Job description

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. Role Summary: The Senior Director, Clinical Practice Liaison (CPL) is a senior leadership role with broader strategic accountability for the CPL function (part of the Field Medical Team at Madrigal) within a defined U.S. region and therapeutic area. This individual will play a pivotal role in shaping the vision, direction, and performance of the CPL team, ensuring the team aligns with and advances the company’s overarching medical strategy, adheres to regulatory and internal policies, and maximizes scientific impact for both internal and external stakeholders. This position will collaborate closely and compliantly with cross-functional colleagues (e.g., Marketing, Sales, Market Access, Clinical Operations, HQ Medical Affairs) and external partners, including healthcare decision-makers and other relevant stakeholders, serving as a key liaison to drive strategic initiatives and influence medical and business outcomes. The position reports to the Executive Director, Field Medical and is a field-based position with travel required within assigned territory. All incumbents are responsible for following applicable Medical Affairs & Madrigal policies and procedures and are compliant with applicable policies, procedures, and regulations. Strong understanding of US regulations and compliance is required. Please note: Candidates may reside anywhere within the Eastern United States. Key Responsibilities and Primary Activities: CPL Team Scientific & Clinical Education Support and help shape the regional strategy for the CPL team to deliver unbiased, evidence-based education on MASH, ensuring CPLs address identified gaps in knowledge and clinical implementation Promote consistent and high-quality communication of clinical practice guidelines and real-world data related to MASH diagnosis, risk stratification, and patient management Maintain strong working knowledge of MASH Non-Invasive Testing (NITs), treatment paradigms, and clinical protocols across the liver/metabolic spectrum, while providing scientific guidance to the team CPL Team Practice Engagement & Enablement Support the Executive Director in the oversight of practice engagement, ensuring CPLs effectively support implementation of MASH care pathways Support adoption of guideline-based approaches, payer-aligned workflows, and quality-driven practice standards across the region. Ensure accuracy and compliance in CPL responses to unsolicited inquiries, reinforcing regulatory expectations Team Leadership & Development Recruit, coach, and manage performance of regional CPLs Foster continuous development through mentoring, structured training, and scientific upskilling Ensure CPL activities align with strategic objectives and tactical plans, supporting consistency and quality in execution Medical Strategy Execution Execute regional field medical strategies in alignment with national d