Scientist, Biologics Purification at AbbVie in Chicago, IL

Job description

Join AbbVie’s Biologics Discovery Sciences group and make a tangible impact in advancing innovative biologic therapies. As a scientist specializing in Biologics Purification, you will play a pivotal role in driving drug discovery, collaborating within a dynamic team dedicated to supporting transformative science that improves patient lives worldwide. You will leverage your expertise to deliver high-purity multi-specific antibody-based biologic candidates with suitable purity/characteristics to support the advancement of vital in vitro (i.e. drug-like property assays, binding, cell-based assays, etc.) and in vivo studies (i.e. efficacy, non-GLP NHP PK, DRF, etc.).   Key Responsibilities:  Lead end-to-end purification campaigns at production-based scales for delivery of high-quality multi-specific antibody biologics to support critical research efforts and program decisions Design and optimize downstream purification strategies using advanced chromatography techniques to remove process impurities, mitigate product liabilities, and achieve target quality attributes Apply deep analytical expertise to characterize molecules, process intermediates, impurities, and final drug candidates, enabling data-driven process decisions   Drive scientific innovation and continuous process improvement by identifying and implementing novel approaches that enhance downstream biologics development workflows Partner across multidisciplinary teams, translating process insights into functional results to accelerate the advancement of therapeutic candidates Communicate scientific findings with clarity and influence, presenting technical information to diverse audiences to support project progression and knowledge sharing BS or MS in Biochemistry, Biophysics, Biomedical, Chemical Engineering, or a related field, with typically 5-7 years (BS) or 2-5 years (MS) of experience  Demonstrated expertise in preparative-scale column chromatography techniques (i.e. affinity, IEX, HIC, multimodal) for antibody-based biologics purification  Hands-on experience operating AKTA chromatography systems and Unicorn software  Strong foundation in analytical characterization techniques, including HPLC, gel electrophoresis, ELISA, mass spectrometry, and related methods  Knowledge of biologics manufacturing or process development is a plus  Solid understanding of protein structure, molecular attributes and post-translational modifications impacting biologic quality and performance  Excellent written, verbal, and presentation skills, with the ability to communicate complex scientific concepts to diverse audiences Track record of scientific curiosity, innovation, and continuous learning Collaborative mindset with a passion for teamwork, scientific rigor, and delivering impactful solutions Position will be filled at level commensurate with extent of education, experience, and accomplishment— Scientist I or Scientist II Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​ The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at  the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors  including  geographic location, and we may ultimately  pay more or less than the posted range. This range may be  modified in the future.&#x