Manager, HR Operations at Amylyx Pharmaceuticals in Cambridge, MA
- Company: Amylyx Pharmaceuticals
- Location: Cambridge, MA
- Salary: $129K – $145K
- Job type: full time
- Workplace: onsite
- Posted: 2026-10-16
All open roles at Amylyx Pharmaceuticals
Job description
Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity The Manager, HR Operations is responsible for supporting the day-to-day operational activities that enable an effective and efficient employee experience across the organization. This role will serve as a key point of contact for employees and HR colleagues, providing support across HR systems and data administration, employee documentation, benefits, payroll coordination, unemployment administration, employee lifecycle transactions, compliance activities, and HR reporting. The Manager, HR Operations will also play an active role in the Company’s ongoing migration to and implementation of Workday, supporting data validation, process design, testing, documentation, implementation activities, and ongoing system optimization. The ideal candidate is highly organized, service-oriented, comfortable working with HR technology and data, and able to operate effectively in a fast-paced, evolving environment. Responsibilities Manage HRIS and employee data administration, including employee data changes, reporting relationships, titles, compensation changes, promotions, transfers, terminations, organizational changes, data audits, and overall data integrity. Serve as a resource for employee HRIS questions, including performance management systems, employee data, system access, and related HR technology inquiries. Support the ongoing migration and implementation of Workday, including data preparation and validation, testing, process mapping, documentation, user acceptance testing, issue identification, and implementation activities. Partner with the Senior Director, HRIS and other HR team members to identify opportunities to improve HR processes, workflows, automation, reporting, and the employee experience through technology. Prepare and manage employment-related documentation, including employment verifications, letters of employment, mortgage and visa letters, benefit coverage letters, and other employee-requested documentation. Coordinate unemployment administration, including state-specific notices and required documentation, claims responses, coordination with state agencies and vendors, hearing preparation, and collection of termination-related information. Provide backup benefits administration support, including employee questions, eligibility and enrollment issues, qualifying life events, benefit coverage confirmation, carrier and vendor escalations, open enrollment, COBRA coordination, and invoice/reconciliation support. Provide backup support for onboarding activities, including new-hire documentation, I-9/E-Verify, background checks, employment eligibility, employee record creation, orientation logistics, and coordination with Payroll and IT. Manage HR operational components of employee offboarding, including termination documentation, final-pay coordination, benefits termination/COBRA, unemployment notices, equipment/process checklists, HRIS termination, and personnel-file documentation. Provide payroll support by coordinating employee changes impacting payroll, new hires and terminations, deductions, taxable benefits, and resolution of employee payroll discrepancies. Maintain accurate and complete ele
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