Director, Project Management Oncology at Jazz Pharmaceuticals in Home-Based, PA

Job description

If you are a current Jazz employee please apply via the Internal Career site Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit www.jazzpharmaceuticals.com for more information. Job Description Brief Description: The Director, Project Management is a senior operational leader within Pipeline and Project Management (PPM) accountable for cross-functional leadership, operational strategy, and integrated execution across high-visibility oncology development programs. Operating as the "COO of the Asset," the PM serves as the strategic operational partner to the Global Project Lead (GPL). This role oversees complex oncology program often spanning multiple indications, coordinating a network of Project Managers across indication teams to harmonize timelines, resolve cross-indication dependencies, and drive alignment to the overarching asset strategy. By establishing a single source of truth across enterprise platforms (Planisware and Smartsheet), driving proactive risk mitigation, and framing decision-ready scenarios for leadership, the PM optimizes the critical path to accelerate innovative therapies to patients. Essential Functions Asset Leadership & Strategy Execution: Partner directly with the Global Project Led to translate the target product profile and clinical development strategy into an executable integrated program plan spanning all target indications. Prepare executive presentations for the asset for governance and executive leaders. Formulate multi-scenario operational models (base-case, accelerated, de-risked) with clear trade-off analyses (speed vs. cost vs. risk vs. value) to provide decision-ready proposals for executive and portfolio governance. Foster High-Performing Teams: Cultivate a purpose-driven, high-performing team culture rooted in psychological safety, transparency, mutual accountability, and urgent collaborative problem-solving across all matrix lines. Multi-PM & Sub-Team Orchestration: Direct and align multiple Project Managers leading specific indication sub-teams and functional workstreams, ensuring harmonized operational standards, milestone alignment, and cohesive delivery across the program. Cross-Functional Matrix Leadership: Lead and influence cross-functional Core Teams (Clinical Development, Regulatory Affairs, CMC/Technical Operations, Nonclinical, Medical Affairs, and Commercial) without formal authority to deliver against program commitments. Timeline Optimization & Critical Path Delivery: Interrogate project assumptions, resolve operational bottlenecks, and compress cycle times across the late-stage development lifecycle through global regulatory filings (NDA/BLA/MAA) and commercial launch. Cross-Indication Interdependency Management: Map, track, and proactively manage critical dependencies across indications (e.g., clinical trial supplies, safety readouts, shared regulatory dossiers) to safeguard overarching program momentum. Single Source of Truth Governance: Maintain baseline data integrity and transparency across enterprise platforms ( Planisware and Smartsheet ) for indication milestones, deliverables, and resource allocations. Risk Register & Mitigation Ownership: Actively lead comprehensive asset risk management, maintain dynamic ri