​​Director, Global Value and Health Economics and Outcomes Research ​ at Jazz Pharmaceuticals in Home-Based, PA

Job description

If you are a current Jazz employee please apply via the Internal Career site Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit www.jazzpharmaceuticals.com for more information. Job Description Brief Description: The Director, Global Value and HEOR is a high-visibility strategic and execution-oriented leadership role responsible for defining and driving the global and US payer evidence strategy for pipeline assets from early clinical development (Phase 2/3) through global regulatory approval and launch. Operating with a dual mandate, the Director leads global payer evidence generation while directly serving as the US HEOR lead, spearheading all US pre-launch HEOR deliverables, payer field enablement tools, and US market access evidence strategies. The Director acts as the vital strategic evidence engine that validates and substantiates the value story developed by Global and US Market Access teams. As a core stakeholder in the Integrated Evidence Generation Plan (IEGP) governance, this role translates target product profiles (TPPs) and access ambitions into methodologically sound evidence generation programs—including early conceptual and global core health economic models, real-world natural history studies, Global Value Dossiers (GVDs), and US AMCP dossiers. The Director serves as the primary conduit to Clinical Development, ensuring global payer, US health plan, and HTA requirements—particularly those unique to rare diseases, such as limited patient cohorts, single-arm designs, surrogate endpoints, and data uncertainty—are proactively integrated into Phase 2 and pivotal Phase 3 study designs. Working in close partnership with regional teams, the Director collaborates directly with the dedicated EU/INT HEOR team to co-develop HTA evidence strategies and deliver robust analytical packages (e.g., indirect comparisons, network meta-analyses, and adaptable core models) for European HTA bodies and the EU Joint Clinical Assessment (JCA). The post holder not only needs to be an excellent strategist, but also be a deep expert delivering projects with vendors, and sometimes doing models etc in house rather than outsourcing them. An ability to create a virtuous circle whereby they use their depth of knowledge to inform strategy, and their knowledge of strategy to inform the evidence that we generate is key to long term success. ​​Essential Functions/Responsibilities ​1. Phase 2/3 Clinical Trial & Early Evidence Integration ​Early Payer & Access Evidence Integration: Partner proactively with Clinical Development Leads, Biostatistics, and Clinical Operations from Phase 2 planning through Phase 3 protocol freeze to ensure global payer, US formulary, and HTA evidence requirements are systematically incorporated into trial designs. ​Trial Protocol Optimization: Advocate for value-enhancing clinical protocol elements, including clinically meaningful active or standard-of-care comparators, optimized inclusion/exclusion criteria, relevant treatment lines, and endpoints recognized by health technology assessors and US commercial/public payers. ​Patient-Centered & Economic Endpoints: Collaborate closely with Patient-Centered Outcomes (PCO) and Clinical teams to integrate validated Patient-Rep