Director, Clinical Operations at CytomX Therapeutics in Emeryville, CA

Job description

Headquarters Location: Emeryville, CA Candidate Location: Hybrid Travel Required: 10% Reports To: Vice President, Clinical Operations Department: Clinical Operations Position Type: Full-time, Exempt About CytomX Therapeutics: CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel PROBODY® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engagers, and immune modulators such as cytokines. CytomX’s clinical-stage pipeline includes CX-2051 and CX-801. Learn more at www.cytomX.com . Who You Are and What You’ll Do: You are passionate about life sciences and making a difference to cancer patients, their families, and healthcare providers. You will lead clinical operations for assigned oncology studies, translating development and functional strategies into executable study plans, clear team priorities, reliable forecasts, and quality delivery. Reporting to the Vice President, Clinical Operations, you will manage and develop employees, oversee external partners, and collaborate across Clinical Development, Biometrics, Regulatory, Quality, CMC, Safety, and other functions. Near-term priorities include strengthening operational readiness for expanding and later-phase studies, advancing study start-up and enrollment execution, and improving scalable processes, metrics, and vendor oversight. Job Responsibilities: Lead end-to-end clinical operations for assigned global studies, including operational planning, start-up, site activation, enrollment, study conduct, closeout, and inspection readiness. Translate program and protocol strategy into integrated operational plans, timelines, budgets, resourcing models, risk assessments, quality measures, and decision points. Independently manage approved study and team resources; monitor forecasts and actuals, identify variances, and recommend actions that protect quality, timelines, and responsible use of resources. Select, contract with, and oversee CROs and other vendors. Establish performance expectations, governance, metrics, escalation pathways, and corrective actions. Partner with cross-functional stakeholders to ensure operational feasibility, timely study-document finalization, site selection and activation, data review, clinical-sample flow, drug-supply continuity, and regulatory deliverables. Use operational data and leading indicators to assess enrollment, monitoring, data entry and verification, queries, action items, TMF completeness, sample reconciliation, and vendor performance; drive timely risk mitigation and escalation. Ensure studies are conducted in accordance with applicable protocols, GCP, regulatory requirements, quality standards, contracts, and internal procedures. Support audits, inspections, and issue remediation. Lead development and continuous improvement of clinical-operations infrastructure, including SOPs, work instructions, tools, templates, dashboards, and scalable ways of working for later-phase readiness. Participate in functional and cross-functional strategy, governance, and portfolio discussions. Present concise operational recommendations, tradeoffs, risks, and decisions to senior stakeholders. Manage, coach, and develop employees. Set clear goals and decision rights, provide timely feedback, support development plans, recognize performance, and build an inclusive, accountable, high-performing team. Delegate appropriately while maintaining oversight of critical decisions, commitments, quality, and deliv