Associate Director, Portfolio Management at Revolution Medicines in Redwood City, CA

Job description

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide. Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients. The Opportunity: Portfolio and Pipeline Strategy helps Revolution Medicines make clear choices as assets, indications, and investment options grow. The Associate Director of Portfolio Management is a late-stage, molecule-facing role that partners closely with Project Teams and Lifecycle Teams to build strong decision packages for pivotal development, registration, launch, and lifecycle decisions. For material decisions, the role adds an enterprise portfolio perspective. It frames the broader questions around a molecule or indication, identifies dependencies and alternatives, and translates clinical, commercial, financial, and strategic insight into comparable portfolio inputs. The role works closely with Disease Area Strategy, asset, Commercial, Development, and Finance teams, as well as other relevant functions and governance partners, to support clear, well-informed decisions. Key Responsibilities Partner with assigned Project Teams and Lifecycle Teams to frame strategic questions and develop decision packages for pivotal development, registration, launch, indication, and lifecycle choices. Partner with teams to develop the fact base for asset decisions—including target product profiles, evidence plans, probability of success, value scenarios, and development options—and translate these inputs into clear portfolio context and implications. Integrate inputs from Development, Commercialization, Finance, Data and Analytics, Disease Area Strategy, and other relevant functions into clear decision briefs and recommendations. Support teams in developing option sets, decision criteria, and Go/No-Go thresholds. Apply asset, disease, and portfolio insight to late-stage and lifecycle choices, including pivotal-trial design, indication strategy, sequencing, and investment. For material decisions, collaborate with teams to assess strategic fit, feasibility, capacity and timing dependencies, competing investments, and what an option enables or displaces. Contribute molecule and indication insights to portfolio reviews, scenarios, path-to-ambition analyses, and prioritization recommendations. Identify when a decision requires broader enterprise perspective and coordinate with portfolio leadership to develop the appropriate analysis. Build trusted working relationships with program and functional leaders through rigorous analysis, constructive challenge, and practical support. Required Skills, Experience and Education: 8 or more years of experience in biotechnology or pharmaceuticals, with experience in drug development, program leadership, portfolio planning, commercialization, strategy, or a closely related field. Strong understanding of late-stage development, registration, commercialization, and lifecycle planning, including the decisions that shape pivotal trials, indication strategy, sequencing, and investment choices. Demonstrated ability to frame complex strategic questions, develop options, assess trade-offs and portfolio implications, and communicate recommendations to senior stakeholders. Experience working across Development, Regulatory, Commercialization, Finance, Data and Analytics, Disease Area Strategy, and other relevant functions to dev