Associate Director, Clinical Project Management at Alector in San Francisco, CA

Job description

Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. By harnessing advancements in genetics, immunology and neuroscience, we are pioneering the development of potential therapies to counteract the devastating progression of neurodegeneration. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history. As Associate Director Clinical Project Management, you will serve end to end operational delivery of assigned clinical trial studies in support of our product development portfolio and will lead the cross-functional clinical trial team and partners with internal and external team members (CROs and vendors) and other key stakeholders ensuring alignment of activities with study projects and timelines (from study concept, initiation, conduct through closeout and associated final deliverables). Clinical Project Manager will translate protocols, contracts, Alector’s neurogenerative disease program requirements into executable study plans and supervises contracted clinical trial activities to study timelines, scope, budget, risks, dependencies, documentation and corporate deliverables. You will bring clarity to ambiguity and complexity by driving cross-functional alignment, enabling timely decision-making, and ensuring disciplined execution across all phases of development. Reporting to the VP of Clinical Development Operations, you will collaborate with leaders and subject matter experts across Research, Development, Clinical, Regulatory, CMC, and other functions to translate strategy into actionable plans, proactively manage risks, and accelerate program progress. We are looking for someone who thrives in a fast-paced, flexible, evolving biotechnology environment, builds trusted relationships across teams, and enjoys improving how work and finding efficiencies where possible. Key Goals & Accountabilities: Develop, maintain, and execute an integrated clinical development plan strategy that advances clinical development objectives while aligning cross-functional priorities. This involves translation of protocols, contracts and study requirements to support overall strategy. Lead cross-functional study teams to make informed decisions, resolve complex issues, and maintain clear, proactive communication across stakeholders worldwide. Design, develop, and manage integrated study project plans with clinical development, including critical path management, scenario planning, milestone tracking, and proactive identification of key risks and opportunities. Routinely re-align contracted vendors to study scope, timelines milestones, deliverables, responsibilities and dependencies. Manages contracts to ensure adequate study activity scope and budget, identify out of scope activities, and support development of change orders, revised budgets, and impact assessments. Develop and maintain effective stakeholder communication across functions including Toxicology, Formulation/CMC, Clinical Development, Regulatory, Clinical Pharmacology, Biometrics, Biomarkers and other technical disciplines to ensure seamless program execution. Informs (as appropriate) on overall clinical trial plans, recruitment status, and raises potential issues/mitigation. Responsible for providing sponsor oversight of clinical study conduct (start-up through database lock and reporting) in compliance with Alector SOPs, FDA/EMA/ other RA regulations, ICH/GCP guidelines and applicable local laws, including review of study documents (protocol, ICF), study presentations, study tools, and study plans (e.g. RBM, IRT, EDC, ePRO, SRM, Recruitment, Laboratory Manuals, etc.) and coordinating cross